ArticleJournal of neuro-oncology2025
The role of MRI patterns in predicting neurologic deficits in spinal ependymomas.
Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Preoperative risk stratification for long-term neurological status in spinal ependymoma: an MRI-centered nomogram.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
objectiveSpinal ependymomas are the most common intramedullary spinal cord tumors, with surgical resection being the primary treatment modality. This study aimed to evaluate the prognostic value of preoperative MRI features in predicting motor deficits in patients undergoing surgery for spinal ependymomas.
methodsWe retrospectively analyzed 71 patients with histopathologically confirmed spinal ependymomas who underwent surgical resection between 2009 and 2021. Preoperative MRI features-including tumor volume, cystic components, syrinx formation, intratumoral hemorrhage, and longitudinal tumor extension-were assessed. Motor strength was recorded pre- and postoperatively. Statistical analysis included univariate comparisons and multivariate logistic regression to identify independent predictors of neurological deficits.
resultsPreoperative motor weakness was significantly associated with syrinx formation (p = 0.012), intratumoral hemorrhage (p = 0.015), and greater tumor length (p = 0.037). Postoperative motor deterioration was significantly correlated with intratumoral hemorrhage (p = 0.025), increased tumor volume (p = 0.007), and longitudinal extension (p = 0.001). In multivariate analysis, the number of vertebral levels involved was the only independent predictor of postoperative motor weakness (OR = 1.737; 95% CI: 1.063-2.838; p = 0.028). No independent predictors were identified for preoperative weakness, although syrinx formation showed a trend toward significance.
conclusionPreoperative MRI findings-particularly intratumoral hemorrhage, syrinx formation, and longitudinal extension-are associated with motor deficits in spinal ependymomas. However, only longitudinal tumor extension was an independent predictor of postoperative neurological deterioration. These findings highlight the importance of comprehensive radiological assessment in preoperative planning and risk stratification. Small sample size and short-term postoperative assessment represent important limitations of this study.
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