Evidence map›Paper›PMID 40663271›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Abnormalities of cortical morphology and structural covariance network in the patients with primary trigeminal neuralgia: a preliminary clinical study.

Hui Xu, Li Jia, Yutao Wang, Wenjing Han, Dan Li, Ming Zhang, Yuan Wang

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02713646 (Applied Research on Patients With Trigeminal Neuralgia by Multi-planar Reconstruction, Curved Planar Reconstruction and Magnetic Resonance Virtual Endoscopy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02713646 completednot on this map

Applied Research on Patients With Trigeminal Neuralgia by Multi-planar Reconstruction, Curved Planar Reconstruction and Magnetic Resonance Virtual Endoscopy

TypeobservationalSponsorFirst Affiliated Hospital Xi'an Jiaotong UniversityRan2016 to 2020Enrolled55ConditionsTrigeminal Neuralgia
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui XuDepartment of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.ORCID http://orcid.org/0000-0003-4514-0413
Li JiaDepartment of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Yutao WangDepartment of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Wenjing HanDepartment of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Dan LiDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Ming ZhangDepartment of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Yuan WangDepartment of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. wangyuan8003@126.com.ORCID http://orcid.org/0000-0002-5692-2659

Funding

Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University XJTU1AF-CRF-2023-030Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University XJTU1AF-CRF-2024-009Key Research and Development Projects of Shaanxi Province 2024SF-YBXM-095Key Research and Development Projects of Shaanxi Province 2025SF-YBXM-328National Natural Science Foundation of China 82171909Wu Jieping Medical Foundation 320.6750.2024-17-18
6 · The paper itself

Abstract

backgroundDespite regional brain structural alterations having been reported in the patients with primary trigeminal neuralgia (PTN), the topological characteristics of structural covariance networks (SCNs) still remain unclear. This study applied graph theoretical analysis to investigate the abnormalities of the global and nodal network patterns of SCNs in PTN.

methodsForty-five patients with PTN and 45 matched healthy controls (HCs) were recruited in this experiment. All of the participants underwent structural magnetic resonance imaging examinations and clinical assessment. The cortical thickness (CT) and cortical surface area (CSA) was extracted from 68 brain regions according to the Desikan atlas, and utilized to reconstruct the SCNs. Subsequently, graph theoretical analysis was performed to evaluate the aberrance of topological properties of the SCNs in patient group.

resultsLocal cerebral atrophy was observed in scattered brain areas, especially in several frontal and medial parietal cortices in the patients with PTN. Specifically, notable changes of nodal degree, local efficiency and betweenness centrality based on CT and CSA were detected in orbitofrontal cortex, anterior cingulate cortex, posterior cingulate cortex, and precuneus. Network analysis revealed that the patient group showed decreased global efficiency of CT and CSA in varying degrees compared to those of HCs.

conclusionsThese findings indicated a distinctive pattern of cortical reorganization of CT and CSA based SCNs in PTN, which is beneficial to understand the pathophysiological mechanism at the level of cortical structural network and provide potential targets for induced neuromodulation in this pain disorder. CLINICAL TRIALS: The registry name of this study in ClinicalTrials.gov: Magnetic Resonance Imaging Study on Patients with Trigeminal Neuralgia (MRI-TN). CLINICALTRIALS: gov ID: NCT02713646. A link to the full application: https://clinicaltrials.gov/ct2/results?cond=%26;term=NCT02713646%26;cntry=%26;state=%26;city=%26;dist= .

Indexed as

Cerebral CortexNerve NetTrigeminal NeuralgiaAdultAgedAtrophyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedCortical surface areaCortical thicknessGraph theoretical analysisPrimary trigeminal neuralgiaStructural covariance networks

Identifiers

PMID40663271

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.