Evidence map›Paper›PMID 40663226›Full record

ArticleAnnals of nuclear medicine2025

Kinetic and quantitative analysis of [

Kotaro Hiraoka, Berihu Mesfin, Yingying Wu, Yuki Shimizu, Asuka Kikuchi, Ryuichi Harada, Aiko Ishiki, Yoshihito Funaki, Shozo Furumoto, Shunji Mugikura and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Astrocyte reactivity across the AD continuum measured by [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Letter to the editor: [Annals of nuclear medicine · 2026
    Article
  4. Whole-body biodistribution of [Annals of nuclear medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kotaro HiraokaNuclear Medicine Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan. khiraoka@raris.tohoku.ac.jp.ORCID http://orcid.org/0000-0003-2422-3121
Berihu MesfinNuclear Medicine Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.
Yingying WuNuclear Medicine Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.
Yuki ShimizuRadiopharmaceutical Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.
Asuka KikuchiNuclear Medicine Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.
Ryuichi HaradaDivision of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Aiko IshikiDivision of Geriatric and Community Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Yoshihito FunakiRadiopharmaceutical Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.
Shozo FurumotoRadiopharmaceutical Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.
Shunji MugikuraDepartment of Diagnostic Radiology, Tohoku University Hospital, Tohoku University, Sendai, Japan.
Nobuyuki OkamuraDivision of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Akio KikuchiDepartment of Occupational Therapy, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Kazuhiko YanaiDepartment of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hiroyuki AraiDepartment of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Hiroshi WatabeDepartment of Diagnostic Radiology, Tohoku University Hospital, Tohoku University, Sendai, Japan.
Manabu TashiroNuclear Medicine Laboratory, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.

Funding

Japan Society for the Promotion of Science 16H06278Japan Society for the Promotion of Science 18H02771Japan Society for the Promotion of Science 18K15357Japan Society for the Promotion of Science 20K07879Japan Society for the Promotion of Science 21H02862
6 · The paper itself

Abstract

BACKGROUND AND

objectiveIn neuroinflammation, activated astrocytes, called reactive astrocytes, highly express monoamine oxidase B (MAO-B). [

methodsDynamic PET scanning of [

resultsThe values of the χ

conclusionsThese findings suggest that SUVR-1, especially at 50-70 min and 70-90 min post-injection, reflects MAO-B distribution and is useful for quantifying [

trial registrationJapan Registry of Clinical Trials (jRCT) (jRCTs021200019). It was registered on August 25, 2020. The jRCT was approved as a member of the Primary Registry Network of the WHO ICTRP.

Indexed as

Fluorine RadioisotopesMonoamine OxidasePositron-Emission TomographyAgedBrainFemaleHumansKineticsMaleMiddle AgedRadiopharmaceuticalsFluorine-18Fluorine RadioisotopesMonoamine OxidaseRadiopharmaceuticals[18F]SMBT-1Monoamine oxidase B (MAO-B)NeuroinflammationPET

Identifiers

PMID40663226
PMCPMC12559039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.