Evidence map›Paper›PMID 40663223›Full record

ArticleMagma (New York, N.Y.)2025

In-vivo liver proton density fat fraction quantification at 0.55 T: a pilot study with comparison against 3 T MRI.

Rochelle E Wong, Bilal Tasdelen, Ye Tian, Darryl Hwang, Sophia X Cui, Liyun Yuan, Krishna S Nayak

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rochelle E WongDivision of Gastroenterology and Hepatology, University of Southern California Keck Medical Center, 1510 San Pablo St., HC1 - Suite 200, Los Angeles, CA, 90033, USA. Rochelle.wong@med.usc.edu.ORCID http://orcid.org/0000-0003-3326-3360
Bilal TasdelenMing Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA.
Ye TianMing Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA.
Darryl HwangDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Sophia X CuiSiemens Medical Solutions, Los Angeles, CA, USA.
Liyun YuanDivision of Gastroenterology and Hepatology, University of Southern California Keck Medical Center, 1510 San Pablo St., HC1 - Suite 200, Los Angeles, CA, 90033, USA.
Krishna S NayakMing Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, USA.

Funding

National Science Foundation 1828736
6 · The paper itself

Abstract

backgroundProton density fat fraction (PDFF)- the ratio of unconfounded fat signal to the sum of the unconfounded fat and water signals, is a valuable quantitative imaging biomarker of metabolic associated steatotic liver disease (MASLD) widely applied in clinical practice and clinical trials. PDFF of the liver is commonly measured using 3 T MRI systems. However, low-field systems are increasingly favored due to lower cost, improved safety profile, minimized artifacts around metallic implants, and enhanced patient comfort.

objectiveIn this pilot study, we used knowledge of standardized and widely used 3 T liver PDFF protocols, and adapted parameters to be appropriate for the 0.55 T MRI. We evaluate a liver fat quantification protocol at 0.55 T compared to a standard clinical 3 T protocol to measure liver fat in patients with MASLD. MATERIAL AND

methodsEight adult patients (average age 53.6 ± 13.6 years, 5 females) with ≥ 5% PDFF on 3 T MRI underwent a 0.55 T MRI PDFF protocol within 90 days. To keep the acquisition time to be within a reasonable breath hold duration and with reasonable signal-to-noise ratio (SNR), four echoes were acquired at a lower resolution and fewer number of slices at 0.55 T compared to 3 T which uses a 6-echo multi-echo Dixon volumetric interpolated breath hold examination (VIBE) protocol. PDFF quantification accuracy of the 0.55 T approach was evaluated using a commercial PDFF phantom and in vivo.

resultsIn the phantom, there was excellent match (R DISCUSSION: Our data demonstrate that 0.55 T MRI is feasible and comparable to 3 T MRI in quantifying liver PDFF among patients with MASLD.

Indexed as

Adipose TissueFatty LiverLiverMagnetic Resonance ImagingAdultAgedArtifactsFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedPilot ProjectsProtonsReproducibility of ResultsSignal-To-Noise RatioProtons0.55 T MRILiver steatosisLow field MRIMid field MRIProton density fat fraction

Identifiers

PMID40663223
PMCPMC12638424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.