ArticleLasers in medical science2025
Neuronal cells' calcium influx modulates in response to 940 nm laser irradiation.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Laser-Based Photobiomodulation for Orthodontic Pain: Mechanistic Evidence from Experimental Tooth-Movement Models.International journal of molecular sciences · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
purposeThis study investigated the effects of 940 nm laser irradiation on calcium influx in trigeminal ganglion neurons. To understand the cellular mechanisms underlying the analgesic effects of photobiomodulation therapy (PBMT), focusing on whether specific laser parameters can modulate neuronal calcium dynamics, which could reduce pain perception.
methodsPrimary cultures of trigeminal ganglia neurons were obtained from C57Bl/6 mice. Neurons were subjected to laser irradiation using a 940 nm InGaAsP semiconductor diode laser with energy density of 9.15 and 17.14 J/cm
resultsLaser irradiation at 65 J significantly reduced intracellular calcium levels immediately after application, with a 50% decrease observed compared to control (p < 0.05). The opioid receptor inhibition study showed lower activity in the laser treated groups compared to control, indicating a potential interaction between photobiomodulation and opioid receptor pathways. However, no significant differences were found in MMP assays between control and laser-treated groups. Our findings suggest that 940 nm photobiomodulation at 65 J effectively inhibits calcium influx in TG neurons, indicating its potential for pain management.
conclusionThis study provides preliminary evidence supporting the potential of 940 nm PBMT to modulate intracellular calcium levels in trigeminal ganglion neurons, which may contribute to its analgesic effects. While only one set of parameters was tested, the findings encourage further investigations aimed at optimizing laser settings and exploring the underlying cellular mechanisms. These results lay important groundwork for future translational studies on the clinical use of PBMT as a non-invasive alternative to pharmacological pain management.
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