ReviewCancer metastasis reviews2025
Metastasis-promoting functions of myeloid cells.
Review in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Myeloid-derived suppressor cells in cancer: biology, regulatory networks and theranostic prospects.Signal transduction and targeted therapy · 2026Review
- T cells are critical for pre-metastatic niche formation through the STAT3/IL-17 axis.Journal for immunotherapy of cancer · 2026Article
- From Bone Marrow Reserve to Metastatic Niche: How Neutrophil-Lineage Cells Shape Skeletal Colonization.International journal of molecular sciences · 2026Review
- A CT-based radiomics model for noninvasive prediction of MMP9 expression and prognostic evaluation in renal cell carcinoma.Medicine · 2026Observational
- Decoding the Role of MDSCs in Bone Metastasis: Multicellular Interactions and Clinical Implications.Pharmaceuticals (Basel, Switzerland) · 2026Review
- The pathoanatomy of cancer: order in paradox.EBioMedicine · 2026Review
- Mechanisms, Imaging Phenotypes, and Therapeutic Advances of Neovascularization in Brain Metastases.Biomedicines · 2026Review
- Cholesterol metabolic rewiring shapes immune remodeling across hepatocarcinogenesis.Frontiers in immunology · 2026Review
- Single-cell atlas reveals a pro-metastatic RELB+ neutrophil-myeloid subset underlying lymph node metastasis in EGFR-wildtype LUAD.Frontiers in cell and developmental biology · 2026Article
- Navigating the Tumor Microenvironment in Colorectal Liver Metastasis: Barriers to Therapy and Emerging Opportunities.Oncology research · 2026Review
- Orchestrating the pre-metastatic niche: roles of stromal mediators and immune cells in metastatic progression and therapeutic targeting.Frontiers in immunology · 2026Review
- Modulation of Human Immune Cells by Propyl-Propane Thiosulfonate (PTSO) Inhibits Colorectal Tumor Progression in a Humanized Mouse Model.Nutrients · 2025Article
- Editorial: Cancer metastases: mechanisms of tumor dissemination, formation of metastatic niche and anti-metastatic therapy.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
The tumor metastatic dissemination and colonization is a highly complex, multi-step process that requires cooperation between cancer and host cells. Among these, cells of myeloid lineage mobilized from the bone marrow are crucial in facilitating tumor metastatic outgrowth. Recent studies indicate that myeloid cells of bone marrow origin, including myeloid-derived suppressor cells (MDSCs), macrophages, and progenitor cells, promote distant metastasis through immunological and non-immunological mechanisms. These cells are key contributors to creating an immunosuppressive microenvironment in the invaded tissue and draining lymph nodes, protecting metastatic cells from immunosurveillance, and promoting resistance to immunotherapy. Furthermore, the myeloid cells mediate the remodeling of the extracellular matrix (ECM) in a metastatic niche via enzymes MMP9 and Hyal2, stimulating angiogenesis and establishing a metastasis-permissive microenvironment. This review describes recent findings demonstrating the metastasis-promoting functions of recruited marrow-derived myeloid cells throughout metastatic colonization and suggests new therapeutic avenues.
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Registered trials
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