ArticleJournal of molecular histology2025
Regulatory effects of head acupuncture on the GABAergic system and Wnt7a/β-catenin pathway in post-stroke spasticity rats.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acupuncture therapy for post-stroke spasticity: a systematic review and exploratory network meta-analysis of clinical efficacy and dose-response relationship.Frontiers in neurologyPooled it
- GABRB3 Gene Polymorphisms Influences the Analgesic Response to Acupuncture Treatment in Patients With Chronic Knee Pain: A Randomized Controlled Neuroimaging Transcriptomics Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Trial
- Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery.Current neurology and neuroscience reports · 2026Review
- Acupuncture and Acupressure for Cancer Symptom Management: an Opinion Statement Based on Preliminary Evidence Mapping.Current treatment options in oncology · 2026Review
- Post-stroke spasticity: advances in network mechanisms and therapeutics.Frontiers in human neuroscience · 2026Review
- Exosome Cargo Molecules and NLRP3/BDNF: Clinical and Preclinical Evidence for Acupuncture-Mediated Spinal Cord Injury Recovery.International journal of general medicine · 2026Review
- Dry Needling of LI4 and TE5 Acupuncture Points on Wrist Flexor Spasticity in Stroke: A Case Report.Case reports in neurological medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
To investigate the regulation of the GABAergic system and Wnt/β-catenin signaling pathway in rats with limb spasticity after stroke by Head Acupuncture therapy and its potential mechanism. A middle cerebral artery occlusion (MCAO) model was established by the thread bolus method, and randomly grouped into a blank group, a model group, and a needling group, the latter of which received the intervention of needling at the points of "Hundred Houses" and "Rate Valley" for 30 min a day for 7 consecutive days. The neurological deficits and muscle tone of rats were assessed by Zeo Longa score and modified Ashworth score, and the expression levels of key proteins of the GABAergic system (GAD65, GAD67, GABA-T, GAT-3, NKCC1) and Wnt/β-catenin signaling pathway were detected by immunohistochemistry, real-time fluorescence quantitative PCR and Western blot and Wnt/β-catenin signaling pathway key protein expression levels. Head Acupuncture significantly improved the neurological deficit score and muscle tone of rats in the model group, decreased the mRNA and protein expression levels of GABA-T and NKCC1, and significantly up-regulated the expression of GAD65, GAD67, and GAT-3. In addition, acupuncture promoted the expression of Wnt7a and β-catenin, and the effect of 7 days of treatment was better than that of 1 day. Head Acupuncture therapy may exert a therapeutic effect on limb spasticity after stroke by regulating the balance of the GABAergic system and activating the Wnt/β-catenin signaling pathway. This provides a new experimental basis for the application of acupuncture in post-stroke sequelae.Clinical trial number: 2024062814.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.