Evidence map›Paper›PMID 40663200›Full record

ReviewLa Radiologia medica2025

Does arterial spin labelling represent a valid alternative to other MR perfusion techniques in neuro-oncology?

Andrea Romano, Allegra Romano, Giulia Moltoni, Giulia de Rosa, Silvia D'Eufemia, Antonella Blandino, Cristiana Monopoli, Lidia Zema, Sara De Giorgi, Sara Tristano and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in La Radiologia medica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Andrea RomanoDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy. andrea.romano@uniroma1.it.ORCID http://orcid.org/0000-0003-0254-9665
Allegra RomanoDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Giulia MoltoniDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Giulia de RosaDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Silvia D'EufemiaDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Antonella BlandinoDiagnostic Imaging Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Cristiana MonopoliDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Lidia ZemaDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Sara De GiorgiDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Sara TristanoDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Tamara IusNeurosurgery Unit, Head-Neck and NeuroSciences Department, University Hospital of Udine, Udine, Italy.
Alessia RegaRadiology Department, Castelli Hospital, Ariccia, Italy.
Vittorio Pio ManciniDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Gabriele MadoniaDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.
Alessandro BozzaoDepartment of Neurosciences, Mental Health and Sensory Organs, School of Medicine and Psychology, "Sapienza" University, S.Andrea Hospital, Via Di Grottarossa 1035, 00136, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review examines the distinctive role of arterial spin labelling (ASL) in neuro-oncology. ASL is a completely non-invasive MRI technique that quantifies cerebral perfusion without exogenous contrast agents, making it an attractive alternative to dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) perfusion-particularly WHEN gadolinium cannot be administered or when serial follow-up studies are required. Unlike DSC, ASL is immune to magnetic susceptibility artefacts, and, unlike DCE, it does not demand lengthy acquisitions or complex post-processing. The available evidence indicates that ASL performs well in grading gliomas and in characterizing brain metastases, lymphomas, and meningiomas. Its superiority over other perfusion methods becomes most apparent in longitudinal follow-up of cerebral gliomas, where it reliably tracks haemodynamic changes, and in assessing tumour-related conditions such as epilepsy and paraneoplastic syndromes. Overall, ASL offers a repeatable and dependable assessment of tumour perfusion and vascularity, thereby supporting more accurate diagnosis, grading, and treatment monitoring in neuro-oncology.

Indexed as

Brain NeoplasmsMagnetic Resonance AngiographyMagnetic Resonance ImagingSpin LabelsCerebrovascular CirculationContrast MediaGliomaHumansContrast MediaSpin LabelsBrain tumoursNeuro-oncologyPCASLPerfusion MRIPseudo-continuous arterial spin labelling

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.