Evidence map›Paper›PMID 40663038›Full record

SynthesisReviews in medical virology2025

Oral Manifestations in the Post COVID-19 Condition: A Systematic Review With Meta-Analysis.

Letícia Simeoni Avais, Elis Carolina Pacheco, Luisa Pereira de Oliveira Zanetti Gomes, Márcia Helena Baldani, Camila Marinelli Martins, Eliseu Alves Waldman, Jean Paul J Gonzalez, Tomoko Y Steen, Pollyanna Kássia de Oliveira Borges

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Reviews in medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Letícia Simeoni AvaisDepartment of Microbiology and Immunology, Georgetown University School of Medicine, Washington, District of Columbia, USA.ORCID 0000-0002-4603-7090
Elis Carolina PachecoGraduate Program in Dentistry, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.ORCID 0000-0003-0409-2881
Luisa Pereira de Oliveira Zanetti GomesUniversity of Joinville (UNIVILLE), Joinville, Brazil.ORCID 0000-0001-7608-5790
Márcia Helena BaldaniDepartment of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil.ORCID 0000-0003-1310-6771
Camila Marinelli MartinsDepartment of Medicine, State University of Ponta Grossa, Ponta Grossa, Brazil.ORCID 0000-0002-6430-2687
Eliseu Alves WaldmanDepartment of Epidemiology, College of Public Health, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-7807-6898
Jean Paul J GonzalezDepartment of Microbiology and Immunology, Georgetown University School of Medicine, Washington, District of Columbia, USA.ORCID 0000-0003-3063-1770
Tomoko Y SteenDepartment of Microbiology and Immunology, Georgetown University School of Medicine, Washington, District of Columbia, USA.ORCID 0000-0002-3482-1849
Pollyanna Kássia de Oliveira BorgesDepartment of Public Health, State University of Ponta Grossa, Ponta Grossa, Brazil.ORCID 0000-0002-9390-0459

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

Post-COVID-19 condition, or Long COVID, is characterised by symptoms persisting or emerging beyond 12 weeks after acute infection. Among over 200 reported symptoms, oral manifestations such as taste loss and dry mouth have been identified. This systematic review reports the frequency and characteristics of these symptoms. Registered in PROSPERO and following PRISMA guidelines, the review included observational studies on COVID-19-positive adults presenting oral symptoms in the post-COVID-19 condition. A search in six databases (Medline/PubMed, Embase, Web of Science, Cochrane, SCOPUS, and LILACS) was conducted in January 2024. Risk of bias was assessed using Joanna Briggs Institute's critical appraisal tools, and certainty of evidence via GRADE. A meta-analysis using the inverse variance method estimated oral symptom prevalence. Of 4552 articles, 107 were included. Taste dysfunction persisted in 8% (95% CI 6%-10%) of patients beyond 12 weeks. Combined taste and smell alterations had a prevalence of 17% (95% CI 13%-21%). Less frequent symptoms included hyposalivation, periodontitis, mouth ulcers, tongue mucosal changes, facial tingling, sensitivity in the trigeminal nerve, difficulty swallowing, and lesions in the hard palate. Taste alterations were the most commonly reported symptom, underscoring the need for clinical recognition and appropriate management by oral health professionals. Additionally, the wide range of other oral manifestations highlights the necessity for further research to better understand their prevalence, underlying mechanisms, and clinical implications in post-COVID-19 patients.

Indexed as

COVID-19Mouth DiseasesTaste DisordersHumansPrevalenceSARS-CoV-2Xerostomialong COVIDoral healthoral manifestationspost‐acute COVID‐19 syndrome

Identifiers

PMID40663038
PMCPMC12262108

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.