SynthesisAnnals of the Royal College of Surgeons of England2026
Incidence, risk factors and prevention of hypothyroidism following laryngectomy: a systematic review and meta-analysis.
Synthesis in Annals of the Royal College of Surgeons of England, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A critical appraisal of qualitative research exploring the lived experience following total laryngectomy.Current opinion in otolaryngology & head and neck surgery · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHypothyroidism following laryngectomy is a well-recognised complication. The symptoms are multisystemic and can cause significant morbidity in patients. We aim to characterise the incidence of hypothyroidism following laryngectomy, and identify risk factors and preventative measures.
methodsA systematic search of EMBASE and PubMed was performed. We appraised relevant articles as per the predefined eligibility criteria. A quality assessment of the included studies was done. A meta-analysis was performed to evaluate the association between reported risk factors and hypothyroidism.
resultsForty articles were included. This encompassed a total of 3,061 patients with a median age of 61 years. Overall incidence of hypothyroidism was 50% (interquartile range: 38.3-75.7). The following factors were significantly associated with hypothyroidism: hemithyroidectomy, odds ratio (OR) 4.84 (95% confidence interval [CI] 3.46-6.77); radiotherapy, OR 4.4 (95% CI 2.29-8.43); and neck dissection, OR 2.63 (95% CI 1.56-4.44). Age, sex, chemotherapy and tumour stage were not significant in the meta-analysis. Preventative measures were based on reducing the extent of thyroid dissection, attention to the preservation of blood supply, and pre- and postoperative thyroid function test monitoring.
conclusionsA significant proportion of patients develop hypothyroidism following laryngectomy. Utilising known risk factors may direct a preventative measure. Further well-designed multicentre observational studies exploring preventative measures including reducing hemithyroidectomy, monitoring intervals of thyroid function and utility of routine thyroxine replacement are required.
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