Evidence map›Paper›PMID 40662949›Full record

ArticleeLife2025

Differential roles of Na

Joshua D Garcia, Chenyu Wang, Ryan P D Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George, Roy Ben-Shalom, David H Hackos and 1 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Functional Characterization of a De NovoNeurology. Genetics · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Neural population dynamics of direct electrical stimulation of neocortex.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Joshua D GarciaWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0002-7572-2062
Chenyu WangWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States.
Ryan P D AlexanderWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States.
Emmie BanksDepartment of Neuroscience, Genentech, Inc., South San Francisco, United States.
Timothy FentonDepartment of Neurology, MIND Institute, University of California Davis School of Medicine, Sacramento, United States.
Jean-Marc DeKeyserDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States.
Tatiana V AbramovaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States.
Alfred L GeorgeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States.ORCID https://orcid.org/0000-0002-3993-966X
Roy Ben-ShalomDepartment of Neurology, MIND Institute, University of California Davis School of Medicine, Sacramento, United States.
David H HackosDepartment of Neuroscience, Genentech, Inc., South San Francisco, United States.
Kevin J BenderWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, United States.ORCID https://orcid.org/0000-0001-7084-1532

Funding

Convergent mechanisms for neurodevelopmental disorder genesR01MH126960 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nadav Ahituv, Kevin J Bender · 2021 to 2026
$3.5M
The function of SCN2A in neocortexR01MH125978 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENDER, KEVIN J · 2021 to 2025
$2.0M
The role of dendritic excitatibility in controlling GABAergic synapse maturationK00MH134674 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Joshua Daylon Garcia · 2023 to 2026
$324k
NIMH NIH HHS K00 MH134674NIMH NIH HHS MH125978NIMH NIH HHS MH126960NIMH NIH HHS MH134674NIMH NIH HHS R01 MH125978NIMH NIH HHS R01 MH126960
6 · The paper itself

Abstract

Mature neocortical pyramidal cells functionally express two sodium channel (Na

Indexed as

NAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelNeocortexPyramidal CellsAction PotentialsAnimalsGene Knock-In TechniquesMiceSulfonamidesNAV1.2 Voltage-Gated Sodium ChannelNAV1.6 Voltage-Gated Sodium ChannelScn2a protein, mouseScn8a protein, mouseSulfonamidesaction potentialdendriteepilepsymouseneurosciencepyramidal cellsodium channel

Identifiers

PMID40662949
PMCPMC12263156

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.