Evidence map›Paper›PMID 40662942›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

SARM1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Enhancing NAD

Hui-Ting Shi, Guo-Jun Zhao, Si-Jia Liu, Bin-Bin Du, Li-Li Xiao, Zhen Huang, Dian-Hong Zhang, Lei-Ming Wu, Yan-Yu Lu, Qi-Guang Du and 2 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Targeting the SARM1-cADPR-CaArthritis research & therapy · 2026
    Article
  3. SARM1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Enhancing NADFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hui-Ting ShiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Guo-Jun ZhaoDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Si-Jia LiuSchool of Basic Medicine, Jinggangshan University, Ji'an, China.
Bin-Bin DuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Li-Li XiaoDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Zhen HuangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0002-0498-1462
Dian-Hong ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Lei-Ming WuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Yan-Yu LuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Qi-Guang DuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Er-Kui WangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Yan-Zhou ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0003-3471-3693

Funding

MOST | National Natural Science Foundation of China (NSFC) 82100283MOST | National Natural Science Foundation of China (NSFC) 82270407The First Affiliated Hospital of Zhengzhou University Research and Innovation Team Excellence Innovation Team ZYCXTD2023016
6 · The paper itself

Abstract

Heart failure (HF) represents the terminal phase in the progression of numerous clinical conditions, with high mortality and significant economic impact. Nicotinamide adenine dinucleotide (NAD

Indexed as

Armadillo Domain ProteinsCardiomegalyCytoskeletal ProteinsHeart FailureNADAnimalsMaleMiceMice, Inbred C57BLMyocytes, CardiacPhenylephrineRatsRats, Sprague-DawleyArmadillo Domain ProteinsCytoskeletal ProteinsNADPhenylephrineSARM1 protein, mousecardiac hypertrophyheart failuremitochondrial dysfunctionNAD+ metabolismsterile alpha and TIR motif containing 1

Identifiers

PMID40662942
PMCPMC12262014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.