ArticleClinical cardiology2025
Trends in Sudden Cardiac Death Related Mortality in Adults in the United States: A CDC WONDER Database Analysis, 1999-2020.
Article in Clinical cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Trends and Demographic Disparities Among Adults With Sudden Cardiac Death and Diabetes Mellitus in the United States: A Nationwide Analysis.Journal of arrhythmia · 2026Article
- Mortality Trends Involving Cardiac Arrest and Fluid, Electrolyte, and Acid-Base Disorders in U.S. Adults, 2004-2024.Journal of clinical medicine · 2026Article
- Article
- Trends and disparities in bone cancer mortality among US adults from 1999 to 2020: a joinpoint regression analysis based on the CDC WONDER database.Frontiers in oncology · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundSudden cardiac death (SCD) is a leading cause of mortality in the United States, with significant variations across demographic and geographic factors. This study analyzes trends in SCD-related mortality among adults (> 25 years) from 1999 to 2020 using the CDC WONDER database.
methodsWe extracted data on SCD-related deaths (ICD-10 code I46.1) and calculated age-adjusted mortality rates (AAMR) per 100 000 population, stratified by sex, race/ethnicity, urbanization, and census region. Joinpoint regression was performed to estimate the annual percent change (APC) and average annual percent change (AAPC) with 95% confidence intervals (CI).
resultsA total of 279 599 SCD-related deaths were recorded from 1999 to 2020. Overall AAMR declined significantly (AAPC: -1.20%; 95% CI: -1.58% to -0.82%) until 2018, followed by a sharp increase from 2018 to 2020 (APC: +6.93%; 95% CI: +3.04% to +10.96%). Declines were most pronounced in American Indian/Alaska Native populations (-3.67%), while the highest increases post-2018 were observed in Hispanic (+13.1%) and Asian/Pacific Islander groups (+12.3%). Urban areas experienced greater post-2018 increases compared to rural areas. Regional disparities were evident, with the West showing the steepest rise in mortality.
conclusionWhile SCD mortality declined from 1999 to 2018, a concerning reversal has emerged since 2018, particularly in specific racial/ethnic groups and urban areas. Further research is needed to investigate underlying causes, including the potential impact of COVID-19, healthcare disparities, and lifestyle factors.
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