Evidence map›Paper›PMID 40662429›Full record

ReviewImmunological reviews2025

Pathological IgE Production in Inborn Errors of Immunity and Beyond.

Cindy S Ma, Peter S Hsu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cindy S MaGarvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.ORCID https://orcid.org/0000-0001-5387-8413
Peter S HsuThe Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Funding

Allergy and Immunology Foundation of Australasia (AIFA)National Health and Medical Research Council (NHMRC) of Australia 2017463
6 · The paper itself

Abstract

In this review, we examine different mechanisms for the generation of pathological IgE through the study of inborn errors of immunity (IEI). In particular, we focus on IEIs that are susceptible to atopic disease, such as severe eczema, eosinophilia, and/or food anaphylaxis; this group of approximately 50 genes has been coined primary atopic disorders (PADs). PADs link specific genes and pathways to atopic disease and the production of IgE and can provide insights into more common allergies experienced by the general population.

Indexed as

HypersensitivityImmunoglobulin EAnimalsFood HypersensitivityHumansImmunoglobulin Eatopic diseaseIgEinborn errors of immunityTh2

Identifiers

PMID40662429
PMCPMC12261389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.