Evidence map›Paper›PMID 40662344›Full record

ReviewJournal of the International Society of Sports Nutrition2025

"Common questions and misconceptions about dietary supplements and the industry - What does science and the law really say?"

Jose Antonio, Brandi Antonio, Alan Aragon, Erik Bustillo, Darren Candow, Rick Collins, Edwin Davila, Bob Durkin, Douglas Kalman, Chris Lockwood and 2 more

Abstract readReview
In one paragraph

Review in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jose AntonioNSU Florida, Department of Health and Human Performance, College of Health Care Sciences, Davie, FL, USA.ORCID 0000-0002-8930-1058
Brandi AntonioUniversity of Central Florida, School of Kinesiology and Rehabilitation Sciences, Orlando, Florida, USA.
Alan AragonLLC. Chatsworth, Fit Advancement, California, USA.
Erik BustilloConcordia University Chicago, Department of Exercise Science, Fit Advancement, River Forest, Illinois, USA.
Darren CandowUniversity of Regina, Faculty of Kinesiology & Health Studies, Regina SK, Canada.ORCID 0000-0002-6655-4482
Rick CollinsCollins Gann McCloskey & Barry PLLC. Mineola, New York, USA.
Edwin DavilaPrecision Health, 7600 Broadway Unit 5023, San Antonio, Texas, USA.
Bob DurkinAmin Wasserman Gurnani, Precision Health, Washington DC, USA.
Douglas KalmanNSU Florida, Department of Nutrition, College of Osteopathic Medicine, Davie, Florida, USA.
Chris LockwoodWoodbolt Distribution LLC dba Nutrabolt, Department of Nutrition, College of Osteopathic Medicine, Austin, Texas, USA.
Scotty MillsUniversity of Regina, Faculty of Kinesiology & Health Studies, Regina SK, Canada.
Jeffrey R StoutUniversity of Central Florida, School of Kinesiology and Rehabilitation Sciences, Orlando, Florida, USA.ORCID 0000-0001-6114-1649

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary supplement use is popular among fitness enthusiasts as well as competitive athletes. There is, however, confusion regarding the regulatory framework as well as the basic science regarding the use of supplements. Although there is an extensive body of scientific and legal writings on dietary supplements, several misconceptions persist vis-à-vis this category. Thus, the following questions will be addressed in this review. 1) Are dietary supplements regulated by the Food and Drug Administration? 2) Are foods and supplements regulated similarly? 3) What is the role of the Federal Trade Commission? 4) Besides federal regulations for dietary supplements, do state laws also regulate the category? 5) If a supplement company funds a study, does that automatically call into question the results? 6) Can diet alone provide everything you need without using supplements? 7) Is it necessary to conduct randomized controlled trials (RCTs) on dietary supplements? 8) How safe are supplements compared to OTC drugs? 9) Where can consumers find accurate information about supplements? 10) Why does the NIH fund dietary supplement research related to disease, yet findings cannot be marketed by supplement companies? 11) What is the size of the dietary supplement industry compared to the pharmaceutical industry? 12) How can I know if a dietary supplement is safe and free of banned substances? Similar to our prior papers, a team of legal and science scholars evaluated the evidence on these salient questions.

Indexed as

Dietary SupplementsLegislation, FoodHumansUnited StatesUnited States Federal Trade CommissionUnited States Food and Drug AdministrationFDAnutritionregulationsafetySocial media

Identifiers

PMID40662344
PMCPMC12265102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.