Evidence map›Paper›PMID 40662320›Full record

Trial reportJournal of cosmetic dermatology2025

Clinical Efficacy Comparisons Between Poly-L-Lactic Acid Injections and Non-Ablative 1565-nm Fractional Laser for Treatment of Striae Distensae-A Randomized Trial.

Huanhuan Qu, Li Wang, Wuyan Xin, Meiheng Lu, Huan Jing, Gang Wang, Lin Gao

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05827913 (Evaluation of the Efficacy and Safety of Polylevolactic Acid Injection Filling Combined With 1565nm Non-ablative Fractional Laser in the Treatment of Striae Distensae), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05827913 naunknown statusnot on this map

Evaluation of the Efficacy and Safety of Polylevolactic Acid Injection Filling Combined With 1565nm Non-ablative Fractional Laser in the Treatment of Striae Distensae

TypeinterventionalSponsorXijing HospitalRan2023 to 2024Enrolled30ConditionsStriae DistensaeArmsPolylevolactic Acid Injection, 1565nm Non-ablative Fractional Laser, Polylevolactic Acid Injection combined with 1565nm Non-ablative Fractional Laser
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huanhuan QuDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0003-1824-3564
Li WangDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Wuyan XinDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Meiheng LuDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Huan JingDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Gang WangDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Lin GaoDepartment of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China.

Funding

National Natural Science Foundation of China 82173436National Natural Science Foundation of China 82373499
6 · The paper itself

Abstract

backgroundDespite numerous treatment modalities for striae distensae (SD), a definitive gold standard therapy remains unidentified.

aimsThis study aims to evaluate and compare the efficacy of injectable poly-L-lactic acid (PLLA) with a 1565-nm non-ablative fractional laser (NAFL) in treating SD located in the abdominal area.

methods40 women with SD were randomly assigned to one of four treatment groups: (1) control, (2) PLLA, (3) 1565-nm NAFL, and (4) a combination of PLLA and 1565-nm NAFL. Participants, except those in the control group, underwent three treatment sessions at monthly intervals. Antera 3D imaging was used to collect data at baseline (T0) and 3 months post-treatment (T4). Collagen fibers were analyzed via immunohistochemical staining, while elastic fibers were assessed using picrosirius red and Masson staining at both T0 and T4.

resultsThe overall efficacy scores for the PLLA, 1565-nm NAFL, and PLLA + 1565-nm NAFL groups were 5.70 ± 1.25, 3.60 ± 2.12, and 6.70 ± 2.21, respectively. Post-treatment evaluations demonstrated substantial decreases in SD volume from T0 to T4, with reductions of -1.96 ± 1.53 in the PLLA group, -0.70 ± 0.67 in the 1565-nm NAFL group, and -1.48 ± 1.35 in the PLLA + 1565-nm NAFL group. The combined and PLLA groups exhibited significant reductions in area compared to the 1565-nm NAFL and control groups. Histological analysis confirmed the presence of PLLA particles in the treated area without inflammatory reactions 1 month post-final injection.

conclusionsPLLA injections are more effective than 1565-nm NAFL in SD treatment, enhancing collagen production without inducing inflammation in treated skin.

trial registrationClinicaltrials.gov: NCT05827913.

Indexed as

Cosmetic TechniquesLasers, Solid-StateLow-Level Light TherapyPolyestersStriae DistensaeAbdomenAdultCollagenFemaleHumansMiddle AgedTreatment OutcomeYoung AdultCollagenPolyesterspoly(lactide)1565‐nm non‐ablative fractional laserbiostimulatorspoly‐L‐lactic acidstriae distensae

Identifiers

PMID40662320
PMCPMC12261269

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.