Evidence map›Paper›PMID 40662191›Full record

ArticleiScience2025

Altered immunometabolic response to fasting in humans living with obesity.

Helena Neudorf, Roderick E Sandilands, Spencer Ursel, Hillary Shaba, Darren Barg, Takeshi Tsusaka, María Dolores Moya-Garzón, Erica Vaz, Patricia Schimweg, Emily L Goldberg and 4 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05886738 (Investigating the Effect of Short-term Fasting on T Cell Metabolism, Function, and Phenotype in Obesity), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05886738 naunknown statusnot on this map

Investigating the Effect of Short-term Fasting on T Cell Metabolism, Function, and Phenotype in Obesity

TypeinterventionalSponsorUniversity of British ColumbiaRan2023 to 2023Enrolled20ConditionsObesity, Fasting, T-Cell DysfunctionArmsFasting
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Helena NeudorfSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Roderick E SandilandsSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Spencer UrselSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Hillary ShabaSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Darren BargSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Takeshi TsusakaDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
María Dolores Moya-GarzónDepartment of Pathology, Stanford University, Stanford, CA, USA.
Erica VazSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Patricia SchimwegDepartment of Sports Science, University of Giessen, Giessen, Germany.
Emily L GoldbergDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Jonathan Z LongDepartment of Pathology, Stanford University, Stanford, CA, USA.
Karsten KrügerDepartment of Sports Science, University of Giessen, Giessen, Germany.
Hashim IslamSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fasting and ketosis are gaining interest for treating obesity-related immunometabolic dysfunction. We aimed to (1) characterize systemic and T cell immunometabolic responses to a 48-h fast in humans and (2) determine if responses differed between individuals with (O-BMI) and without (L-BMI) obesity (n = 16 per group). Despite similar increases in systemic fat oxidation, increases in blood β-hydroxybutyrate (BHB), BHB-amino acid conjugates, and lysine β-hydroxybutyrylation were blunted in obesity. T cells from the L-BMI group upregulated their relative capacity for fat oxidation while the O-BMI group did not. The O-BMI group had a greater proportion of Th17 cells and secreted more interleukin-17 (IL-17), even after fasting. CD8 expression decreased in both groups and CD4 expression only decreased in the L-BMI group. The balance of anti-to pro-inflammatory cytokines increased less in the O-BMI group. Collectively, these findings show that humans living with obesity have a blunted systemic and T cell immunometabolic response to fasting. NCT05886738.

Indexed as

human metabolismimmunology

Identifiers

PMID40662191
PMCPMC12256293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.