ArticleInternational journal of genomics2025
Exploring the Genetic Basis of Ketosis: Preliminary GWAS Findings on Beta-Hydroxybutyrate Levels in Holstein Cattle.
Article in International journal of genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ketosis is a metabolic condition characterized by a shift in energy metabolism, occurring when glucose availability is depleted and fat becomes the alternative primary energy source, resulting in the accumulation of ketone bodies. In dairy cattle, ketosis represents a significant challenge, adversely affecting both animal health and farm productivity. The genetic basis of ketosis in cattle has attracted increasing attention, with genome-wide association studies (GWAS) emerging as a crucial method for identifying relevant genetic factors. This study was aimed at investigating genome-wide regions associated with beta-hydroxybutyrate (BHB) concentrations in Holstein-Friesian cows' blood before calving in the United Kingdom. BHB measurement data from 253 previously genotyped cows were used in the analyses. The results revealed five significant SNPs on Chromosome 15 (BTA15) and one significant SNP on BTA5 (
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