ArticleCurrent medical mycology2024
Transcriptomics Insights into Targeting CK2 Complex in
Article in Current medical mycology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
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Abstract
Background and purpose: Materials and Methods: The study used computational methods to explore the transcriptomic and functional aspects of the Ck2 complex and other pathogenic proteins in Results: The RNA-sequencing analysis resulted in various dysregulated genes such as 936 (cka1Δ mutant vs wild), 1154 (triple vs wild), and 1159 (wild vs all mutants). Cellular components, molecular functions, and KEGG pathways in three conditions. The hub genes that elevated the most, Q5KFT2_CRYNJ, ARO1_CRYNJ, Q5KL19_CRYNJ, Q5KC42_CRYNJ, Q5KNI6_CRYNJ, Q5KCS1_CRYNJ, Q5KNH2_CRYNJ, Q5KA46_CRYNJ, Q5KEV1_CRYNJ, Q5KFT0_CRYNJ, Q5KAB9_CRYNJ, Q5KN73_CRYNJ, Q5KLJ6_CRYNJ, and Q5KHQ2_CRYNJ, were selected for FDA-approved drugs screening using GNINA, resulting in three potential drugs (amphotericin B, idarubicin, and candicidin) for respective proteins. Conclusions: The Ck2 complex in
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