ArticleFrontiers in cardiovascular medicine2025
Shifting landscapes: dynamic changes from pro- to anti-inflammatory leukocyte phenotype in myocardial ischemia/reperfusion injury.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The temporal and spatial dynamics of platelet-leukocyte complex (PLC) formation in myocardial ischemia reperfusion injury (I/R injury) are still ill defined. Aim: To investigate the kinetics and spatial differences of platelet-monocyte (PMC) and platelet-neutrophil (PNC) complex formation over the first 7 days in a mouse model of myocardial I/R injury. Methods: A time-course study was conducted up to 7 days in order to evaluate immune cell response and cardiac function following myocardial I/R injury in mice. Myocardial I/R injury was induced by ligation of the left anterior descending coronary artery (LAD) for 30 min followed by reperfusion. Using flow cytometry leukocyte and platelet markers were evaluated in the heart, blood, spleen, and bone marrow. Echocardiography was performed in order to measure ejection fraction and fractional shortening which are accepted indicators of cardiac function. Results: Expression of CD206-Geometric Mean Fluorescence Intensity (GMFI) indicative of an anti-inflammatory phenotype in neutrophils (N2) increased in PNCs at day 7. A statitstically significant decrease in the percentage of anti-inflammatory Ly6C Conclusion: The present study demonstrates that both anti-inflammatory Ly6C
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