ArticleFrontiers in microbiology2025
Genomic evolution and ecotype divergence in thraustochytrids: insights from comparative genomics and phylogenomics.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Genomic signatures of cold adaptation in a Himalayan drosophilid.G3 (Bethesda, Md.) · 2026Article
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6 authors.
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Abstract
Background: Thraustochytrids are unicellular heterotrophic protists within the Stramenopiles group, widely distributed across marine ecosystems. Understanding the mechanisms underlying their metabolic ecotype evolution is pivotal for revealing how these organisms drive the marine carbon cycle and adapt to diverse environments. Methods: In this study, we report a high-quality genome of Results: Comparative genomics revealed that "anabolic" strains (TWZ-97, Mn4, SW8) possess larger genomes with lower gene density, whereas "catabolic" strains (S-28, S-429) have smaller, gene-rich genomes with stable repetitive elements. Phylogenetic analyses revealed that the "anabolic" strains diverged relatively recently, around 2.389 million years ago, while the "catabolic" strains evolved independently for over 190.7 million years, reflecting prolonged, lineage-specific adaptation. Functionally, "anabolic" strains were enriched in fatty acid synthase genes, whereas hydrolytic enzyme genes were unique to the "catabolic" strains. Both ecotypes exhibited a significant abundance of fatty acid desaturase (FAD) genes, and polyketide synthase (PKS) genes displayed unique long sequences, multi-domain architectures, and ecotype-specific gene differentiation patterns. Conclusion: Together, this study provides crucial molecular evidence for the genetic basis of metabolic specialization and ecotype diversification in thraustochytrids.
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