ArticleFrontiers in immunology2025
Cellular senescence defining the disease characteristics of Crohn's disease.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- From a Multi-Omics Signature to a Therapeutic Candidate: Computational Prediction and Experimental Validation in Liver Fibrosis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment.Aging cell · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Crohn's disease (CD) is a complex and heterogeneous inflammatory disease whose most important feature is immune dysregulation. As a basic cell response, cellular senescence (CS) can regulate the immune response involved in a variety of inflammatory diseases. However, the role of CS in the pathogenesis and diagnosis prediction of CD are still unknown. Methods: We utilized CD-related datasets from the GEO database for differential gene expression analysis, and CS related differentially expressed genes (CSRDEGs) in CD by a comprehensive bioinformatics analysis encompassing GSEA, WGCNA, and various interaction networks. The support vector machine (SVM) algorithm, random forest algorithm and LASSO regression analysis was used to construct a diagnostic model. And based on CSRDEGs, we further constructed a Cellular senescence score (CSscore) model. Different disease subtypes (cluster1/cluster2) were identified by the consensus clustering method. The assessment of immune cell infiltration and its correlation with CSRDEGs was analyzed by ssGAEA and CIBERSORT. Results: We identified 10 hub CS related differentially expressed genes (CSRDEGs) in CD. Based on CSRDEGs, we further constructed a diagnostic model (AUC = 0.880) containing 5 CSRDEGs ( Conclusions: These results suggest that CS is an important feature of CD, and CSRDEGs can be used to construct disease diagnostic models and distinguish disease subtypes. Further investigation of the mechanism of immune dysregulation caused by CS can deepen our understanding of the pathogenesis of CD.
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