Evidence map›Paper›PMID 40661952›Full record

Observational studyFrontiers in immunology2025

Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children.

Maximilian Seidl, Elham Bavafaye Haghighi, Anne Kathrin Lösslein, Markus Hufnagel, Florens Lohrmann, Christian Schneider, Daniela S Kohlfürst, Werner Zenz, Gregor Gorkiewicz, Cornelia Feiterna-Sperling and 8 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maximilian Seidl *Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Elham Bavafaye Haghighi *Department of Tissue Dynamics and Regeneration, Max Planck Institute for Multidisciplinary Sciences, Goettingen, Germany.
Anne Kathrin LössleinInstitute for Microbiology and Hygiene, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Markus HufnagelDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Florens LohrmannInstitute for Infection Prevention and Control, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Christian SchneiderInstitute for Microbiology and Hygiene, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Daniela S KohlfürstDepartment of Pediatrics and Adolescent Medicine, Division Pediatric Hemato-Oncology, Medical University of Graz, Graz, Austria.
Werner ZenzDepartment of Paediatrics and Adolescent Medicine, Division of General Paediatrics, Medical University of Graz, Graz, Austria.
Gregor GorkiewiczDiagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.
Cornelia Feiterna-SperlingDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Renate KrügerDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Peter BronsertCenter for Pathology, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Christina NepplInstitute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf, Duesseldorf, Germany.
Kim Zoe SommerInstitute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf, Duesseldorf, Germany.
Verena StehlInstitute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf, Duesseldorf, Germany.
Melanie BoerriesInstitute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Martin KuntzInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.
Philipp HennekeInstitute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center - University of Freiburg/Medical Faculty - University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Infections with non-tuberculous mycobacteria (NTM) in children usually affect the lymph nodes and surrounding tissue. Although the infection is typically self-limiting, it carries a substantial risk of complications due to persistent inflammation and invasive therapeutic interventions. Yet, the immunopathogenesis of the disease is obscure, as are biomarkers guiding treatment decisions. Methods: In this observational study, we analyzed histological samples collected in the NTMkids study to identify parameters associated with impaired wound healing and complicated disease progression. Samples from 33 patients (median age at first presentation 33 months) were investigated, with two consecutive biopsies in 9 patients. Results: Germinal centers, a scattered distribution of granuloma associated CD4+ T-cells, higher CD8+ T-cell density inside the necrosis and foamy epitheloid cells were associated with a favorable outcome. Tissue damage presenting clinically as liquefaction was associated with an adverse outcome. Conclusions: The identified tissue reaction patterns in NTM infections provide insights into the biology of NTM lymphadenitis in children and may aid in more precise treatment decisions.

Indexed as

LymphadenitisMycobacterium Infections, NontuberculousNontuberculous MycobacteriaBiopsyCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChildChild, PreschoolFemaleGerminal CenterHumansInfantLymph NodesMalechildrencomplicationsgiant cellsgranulomahistologylymphadenitisnon-tuberculous mycobacteria

Identifiers

PMID40661952
PMCPMC12257029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.