Bioinformatics-based analysis of nicotinamide adenine dinucleotide metabolism-related genes to predict immune status and prognosis for head and neck squamous cell carcinoma patients.

Zhenjie Guan, Xinyu Gu, Lian Zheng

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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3 authors.

Zhenjie GuanDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Xinyu GuDepartment of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Zhengzhou, China.

Lian ZhengDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients suffering from head and neck squamous cell carcinoma (HNSCC) have a high recurrence rate and poor prognosis. Nicotinamide adenine dinucleotide (NAD Methods: First, weighted gene co-expression network analysis (WGCNA) was utilized to screen gene modules linked to NAD Results: Here, we screened two specific modules with the strongest relation to HNSCC by WGCNA and subsequently took the intersection of 6160 DEGs with the module genes, obtaining a total of 359 intersected genes. 6 ( Conclusions: The current work provided theoretical references for future study on potential biomarkers of prognosis and immune infiltration in patients suffering from HNSCC.

Indexed as

Biomarkers, TumorComputational BiologyHead and Neck NeoplasmsNADSquamous Cell Carcinoma of Head and NeckCell Line, TumorGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMutationPrognosisBiomarkers, TumorNADgene mutationhead and neck squamous cell carcinomaimmune infiltrationprognostic modelingWGCNA analysis

Identifiers

PMID40661938

DOI10.3389/fimmu.2025.1609175

PMCPMC12256497

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.