Trial reportDrug design, development and therapy2025
Effects of Dexmedetomidine on Minimum Alveolar Concentration of Sevoflurane for Blunting Sympathetic Response to Pneumoperitoneum: A Randomized Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Laparoscopic procedures require abdominal inflation (pneumoperitoneum), which triggers strong stress responses that typically need high concentrations of sevoflurane to manage. Despite dexmedetomidine's known anesthetic-sparing properties, its specific effects on sevoflurane minimum alveolar concentration for blunting sympathetic response (MAC Patients and Methods: This prospective, randomized, double-blind, placebo-controlled trial enrolled 90 adults (aged 18-45 years) classified as American Society of Anesthesiologists physical status I-II scheduled for elective laparoscopic cholecystectomy. Participants received either saline, low-dose dexmedetomidine (target 0.3 ng/mL), or high-dose dexmedetomidine (target 0.6 ng/mL). We determined sevoflurane MAC Results: Dexmedetomidine significantly reduced sevoflurane MAC Conclusion: Dexmedetomidine produces dose-dependent reductions in sevoflurane requirements for controlling sympathetic responses during pneumoperitoneum while maintaining hemodynamic stability, making it a valuable adjunct for anesthesia in laparoscopic surgery. Registration: The Chinese Clinical Trials Registry, ChiCTR2300071257.
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