Evidence map›Paper›PMID 40661798›Full record

ArticleFood science & nutrition2025

Genetic Evidence on the Role of Blood Phytosterols in Frailty: A Mendelian Randomization Study.

Guangyu Gao, Tianci Yao, Chengyun Liu, Haohui Fan, Xinyue Zhang, Hao Zhang, Xiaofang Zhao, Bei Song, Kun Wang, Ting Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guangyu GaoDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Tianci YaoDepartment of Endocrinology Yueyang Central Hospital Yueyang China.
Chengyun LiuDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Haohui FanDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Xinyue ZhangDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Hao ZhangDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Xiaofang ZhaoDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Bei SongDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Kun WangDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Ting LiuDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Xueke GuangDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Quan ZhouDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.
Weilin LuDepartment of Geriatrics, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China.ORCID https://orcid.org/0009-0000-5400-7185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytosterols have been recommended as a lifestyle intervention for early lipid management-which has a significant impact on frailty. However, their effect on frailty remains unclear. Studies have shown that genetic proxied total blood phytosterol affects the development of cardiovascular disease through non-HDL-c and apolipoprotein B mediation, which makes phytosterol an underlying risk factor for frailty. The aim of this Mendelian randomization (MR) study was to investigate the genetic associations between phytosterols and frailty. We used univariate Mendelian randomization (UVMR) to assess the causal effects of blood phytosterols on the Frailty Index (FI) and Fried Frailty Score (FFS). We also employed multivariate Mendelian randomization (MVMR) and Two-step MR (TSMR) to evaluate the mediating role of blood lipids in the relationship between blood phytosterols and FI. We used the product of coefficients method to calculate the mediating effect. The inverse-variance weighted method was used as the primary analysis. Genetically proxied higher levels of blood total sitosterol were significantly associated with a higher risk of Frailty Index (OR = 1.035, 95% CI = 1.009-1.061,

Indexed as

frailtyMendelian randomizationphytosterol

Identifiers

PMID40661798
PMCPMC12257141

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.