Evidence map›Paper›PMID 40661747›Full record

ArticleFrontiers in endocrinology2025

Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein

Zhen Wang, Fujia Chen, Yun Li, Chaoying Liu, Lizhen Wang, Weilun Shao, Zhen Lu, Li Hu, Longxuan Li, Yue Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Phytochemical properties ofFrontiers in pharmacology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhen Wang *School of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Fujia Chen *School of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Yun LiSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Chaoying LiuSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Lizhen WangBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Weilun ShaoAix-Marseille University College, Wuhan University of Technology, Wuhan, China.
Zhen LuSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Li HuSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Longxuan LiSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Yue WangSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Jinyang LinSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Yaxuan YuSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Shengjun SunResearch & Development (R&D), Henan Dadeguang Animal Pharmaceuticals Co., Ltd., Pingdingshan, Henan, China.
Yurong YangSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Zhijian ZhuSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Siqiang LiSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.
Enzhong LiSchool of Biological and Food Processing Engineering, Institute of Agricultural Products Fermentation Engineering and Application, Huanghuai University, Zhumadian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Curcumin has garnered increasing attention in male reproductive research due to its potential anti-infertility properties. This study aimed to explore the protective effects of curcumin on spermatogenesis impairment in mice with cryptorchidism and to elucidate the underlying mechanisms. Methods: A total of 56 male Kunming mice aged 10 to 15 days were randomly assigned to different groups, including a control group (BO) and a cryptorchid group with five curcumin treatment groups (CC25, CC50, CC100, CC200, and CC300) receiving varying doses of curcumin (25, 50, 100, 200, and 300 mg/kg, respectively). After five weeks of treatment, evaluations based on organ coefficients, sperm count detection, testicular pathology analysis, and hormone level assessments determined the most effective curcumin dosage. Results and disccusion: The findings indicated that cryptorchidism had a detrimental impact on reproductive function, evident by decreased testicular coefficient, cessation of sperm production, abnormal testicular tissue morphology, and hormonal imbalances. Curcumin treatment mitigated these abnormalities, with the most significant improvement observed at a dosage of 100 mg/kg, without substantial adverse effects on other organs. Mechanistic studies revealed that cryptorchidism reduced testicular protein

Indexed as

CryptorchidismCurcuminSpermatogenesisTestisAnimalsMaleMiceCurcumincryptorchidismcurcuminO-GlcNAcylationspermatogenesistesticular protein

Identifiers

PMID40661747
PMCPMC12256208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.