ArticleFrontiers in endocrinology2025
Association between dietary selenium intake and endometriosis risk: a cross-sectional analysis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association between total dietary sugar intake and gallstones in Americans.Scientific reports · 2026Article
- Nutrition and Endometriosis: Current Evidence on Dietary Risk Factors and Clinical Impact - A Narrative Review.Journal of inflammation research · 2026Review
- Association between the composite dietary antioxidant index and chronic rhinosinusitis burden: the potential mediating role of insulin resistance.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endometriosis (EMs) is a common chronic inflammatory disorder with estrogen dependency, and its causes and progression are not fully understood. With limited treatment options available, the dietary impact on EMs incidence has gained research interest. This study explores the link between dietary selenium intake and EMs risk, noting selenium's key antioxidant role in reducing oxidative stress and inflammation, and its potential to modulate immune responses, offering protective effects. Methods: The study included 39,352 participants from National Health and Nutrition Examination Survey (NHANES) data (1999-2006). We excluded individuals with missing data on dietary selenium intake or EMs status, pregnant women, and individuals with missing basic covariate data or suspected erroneous dietary selenium intake values. After these exclusions, a final cohort of 3,876 participants was included for detailed analysis. This cohort was stratified into two groups: 3566 individuals without a diagnosis of endometriosis and 310 individuals diagnosed with EMs. The relationship between EMs and dietary selenium intake was examined using a suite of statistical methodologies, including multivariate logistic regression to control for confounding variables, smooth curve fitting, threshold effect analysis and subgroup analysis. Results: After adjusting for multiple covariates, the multivariate logistic regression model indicated a negative correlation between dietary selenium intake and the risk of developing EMs. In the highest dietary selenium intake group, the adjusted model II revealed a reduction in the risk of EMs by approximately 34.1% (OR = 0.659, 95% CI: 0.449, 0.967). The subgroup analysis revealed a negative relationship between quartiles of selenium intake and the risk of endometriosis in participants aged fifty years and older, in non-Hispanic white participants, in participants with PIR >=1.3 and <3.5, in participants with a high school education level or under, in participants who get married or live with a partner, in participants who have never drunk, and in participants who smoke currently. Conclusions: Our findings suggest a negative correlation between dietary selenium intake and endometriosis risk. However, potential confounding factors may influence this association. Given the limitations of this cross-sectional study, such as reliance on self-reported data, further prospective research is required to confirm causality and explore underlying mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.