Observational studyFrontiers in endocrinology2025
Non-linear association between low-density lipoprotein cholesterol and risk of prediabetes: a retrospective cohort study based on Chinese adults.
Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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3 authors.
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Abstract
Background: The pathogenesis of prediabetes remains complex, particularly regarding the interactions between lipid metabolism disorders and glucose metabolism abnormalities, which warrant in-depth exploration. Low-density lipoprotein cholesterol (LDL-C) is an important risk factor for atherosclerosis and cardiovascular disease. However, the relationship between LDL-C and prediabetes has been less extensively studied. Therefore, we conducted a retrospective cohort study to investigate this association. Methods: This secondary retrospective cohort study utilized data from 100,608 Chinese adults. Cox proportional hazards regression models were used to examine the relationship between LDL-C and prediabetes risk. Restricted cubic spline regression and smooth curve fitting were used to explore the non-linear relationship between LDL-C and prediabetes. A two-piecewise Cox proportional hazards regression model identified inflection points. In addition, a series of subgroup and sensitivity analyses were performed to confirm the robustness of our results. Results: After adjusting for confounding covariates, LDL-C was positively associated with prediabetes (HR: 1.49, 95% CI: 1.40-1.58, p < 0.0001). The two-piecewise Cox model identified an inflection point of 2.19 for LDL-C (p < 0.001 for log-likelihood ratio test). When LDL-C ≤ 2.19, LDL-C was positively associated with the risk of prediabetes (HR: 2.02, 95% CI: 1.71-2.36, p < 0.0001). In contrast, when LDL-C > 2.19, LDL-C was associated with a lower risk of prediabetes (HR: 1.49, 95% CI: 1.39-1.59, p < 0.0001). Sensitivity and subgroup analyses confirmed the stability and consistency of this positive association in the general population. Conclusion: This study reveals a non-linear positive association between LDL-C levels and prediabetes risk in Chinese adults after adjusting for confounders. The dynamic monitoring of LDL-C levels may help identify individuals at high risk for prediabetes. Timely dietary and lifestyle modifications could potentially reduce the risk of prediabetes. These findings offer new insights for prediabetes prevention and treatment.
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