Evidence map›Paper›PMID 40661631›Full record

ArticlebioRxiv : the preprint server for biology2025

Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model.

Yaroslav I Molkov, Florent Krust, Russell Jeter, Tommy Stell, Mohammed A Y Mohammed, Frédéric Brocard, Ilya A Rybak

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yaroslav I MolkovDepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA, USA.ORCID 0000-0002-0862-1974
Florent KrustInstitut de Neurosciences de la Timone, Aix Marseille University, CNRS, Marseille, France.
Russell JeterDepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA, USA.ORCID 0000-0002-3019-2387
Tommy StellDepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA, USA.
Mohammed A Y MohammedDepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA, USA.
Frédéric BrocardInstitut de Neurosciences de la Timone, Aix Marseille University, CNRS, Marseille, France.ORCID 0000-0001-9444-9586
Ilya A RybakDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0003-3461-349X

Funding

Mechanisms of locomotor rhythm generation in rodent spinal cordR01NS130799 · NINDS · DREXEL UNIVERSITY · PI Kimberly J Dougherty, Ilya A Rybak · 2022 to 2026
$2.6M
NINDS NIH HHS R01 NS130799
6 · The paper itself

Abstract

Spinal motoneurons are the final output of spinal circuits that engage skeletal muscles to generate motor behaviors. Many motoneurons exhibit bistable behavior, alternating between a quiescent resting state and a self-sustained firing mode, classically attributed to plateau potentials driven by persistent inward currents. This intrinsic property is important for normal movement control, but can become dysregulated, causing motor function deficits, like spasticity. Here we use a conductance-based single-compartment model, together with mouse spinal slice recordings,to investigate the ionic interactions underlying motoneuron bistability. We show that synergistic interactions among high-voltage-activated L-type Ca

Identifiers

PMID40661631
PMCPMC12258988

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.