Evidence map›Paper›PMID 40661614›Full record

ArticlebioRxiv : the preprint server for biology2025

Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variants.

Anne E van Vlimmeren, Lauren C Tang, Ziyuan Jiang, Abhishek Iyer, Rashmi Voleti, Konstantin Krismer, Jellert T Gaublomme, Marko Jovanovic, Neel H Shah

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Anne E van VlimmerenDepartment of Chemistry, Columbia University, New York, NY 10027.ORCID 0000-0003-0379-4945
Lauren C TangDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0001-8786-5418
Ziyuan JiangDepartment of Chemistry, Columbia University, New York, NY 10027.ORCID 0009-0003-6035-4126
Abhishek IyerDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0009-0009-3700-2994
Rashmi VoletiDepartment of Chemistry, Columbia University, New York, NY 10027.ORCID 0000-0002-3705-7460
Konstantin KrismerKoch Institute for Integrative Cancer Biology, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0000-0001-8994-3416
Jellert T GaublommeDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0002-1266-052X
Marko JovanovicDepartment of Biological Sciences, Columbia University, New York, NY 10027.ORCID 0000-0001-9707-3377
Neel H ShahDepartment of Chemistry, Columbia University, New York, NY 10027.ORCID 0000-0002-1186-0626

Funding

SPATIALLY MAPPING OF POOLED IN VIVO CRISPR SCREENS IN THE TUMOR MICROENVIRONMENTDP2CA281605 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GAUBLOMME, JELLERT · 2022 to 2025
$2.5M
Probing tyrosine phosphatase structure and functionR35GM138014 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHAH, NEEL H · 2020 to 2024
$2.3M
How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changesR35GM152258 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Marko Jovanovic · 2024 to 2026
$1.6M
NCI NIH HHS DP2 CA281605NIGMS NIH HHS R35 GM138014NIGMS NIH HHS R35 GM152258
6 · The paper itself

Abstract

Missense mutations in

Indexed as

mitochondriaphosphotyrosineprotein-protein interactionSHP2TurboIDtyrosine phosphatase

Identifiers

PMID40661614
PMCPMC12258515

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.