Evidence map›Paper›PMID 40661593›Full record

ArticlebioRxiv : the preprint server for biology2025

Acute induction of IFNα is responsible for the attenuation of the live measles vaccine.

Jerome M Edwards, Steve Yoon, Jacqueline Brockhurst, Linda J Rennick, W Paul Duprex, Isabelle Coppens, Andrew Pekosz, Diane E Griffin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jerome M EdwardsW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Steve YoonW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Jacqueline BrockhurstW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Linda J RennickCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
W Paul DuprexCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, 15260, USA.ORCID 0000-0003-1716-6376
Isabelle CoppensW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.ORCID 0000-0003-3248-1761
Diane E GriffinW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Immunological and Physiological Responses to Measles VaccineR01AI182066 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Nicole Baumgarth, Andrew S. Pekosz · 2024 to 2026
$2.3M
Measles virus infection of the respiratory tractR01AI153140 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PEKOSZ, ANDREW S. · 2020 to 2024
$2.0M
NIAID NIH HHS R01 AI153140NIAID NIH HHS R01 AI182066NIAID NIH HHS T32 AI007417
6 · The paper itself

Abstract

The live-attenuated measles vaccine (LAMV) protects against measles in a safe, efficacious and durable manner. However, the mechanism by which LAMV is attenuated is not well understood, contributing to the increased vaccine hesitancy that has caused a worldwide resurgence of measles. Here, we provide a molecular model of attenuation that implicates increased host innate immune responses and increased LAMV susceptibility to those responses. Our study leverages both

Identifiers

PMID40661593
PMCPMC12259043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.