ArticlebioRxiv : the preprint server for biology2025
Stroke-Related Changes in Tonic and Phasic Muscle Recruitment During Reaching Reveal Pathway-Specific Motor Deficits.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Upper limb motor deficits are common after stroke and often persist despite rehabilitation. While clinical assessments emphasize movement quality, they do not capture the underlying neuromuscular impairments, particularly in individuals with mild deficits. This study aimed to characterize stroke-related changes in muscle recruitment during reaching by separating tonic (gravity-compensating) and phasic (intersegmental dynamics-related) components of EMG activity. We recorded surface EMG from 12 upper limb muscles during goal-directed reaching in 8 individuals with unilateral ischemic stroke and 9 controls. Using principal component analysis, we extracted tonic and phasic components and compared their amplitude, directional tuning, and coactivation patterns across groups. Group differences were evaluated with generalized linear mixed-effects models, regression, and correlation analyses. Even individuals with mild stroke exhibited abnormal muscle recruitment. Proximal muscles were over-recruited in directions that typically require less activation, indicating altered directional tuning. Phasic activation of distal muscles was significantly reduced and worsened with time post-stroke (R
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