Evidence map›Paper›PMID 40661559›Full record

ArticlebioRxiv : the preprint server for biology2025

Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies.

Silas A Buck, Tuyana Malankhanova, Eileen B Ma, Sarah Yim, Harrison W Pratt, John Ervin, Shih-Hsiu J Wang, Todd J Cohen, Andrew B West, Laurie H Sanders

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Silas A BuckDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0002-9476-9210
Tuyana MalankhanovaDuke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.
Eileen B MaDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Sarah YimDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Harrison W PrattDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
John ErvinDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Shih-Hsiu J WangDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.
Todd J CohenDepartment of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Andrew B WestDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0002-3034-4061
Laurie H SandersDepartment of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.ORCID 0000-0003-1617-9562

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Research Education Component CoreP30AG072958 · NIA · DUKE UNIVERSITY · PI Maria Marquine · 2021 to 2026
$24.1M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin, Corey T McMillan · 2020 to 2026
$18.8M
Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of SynucleinopathyP01AG084497 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DANIEL WEINTRAUB · 2024 to 2026
$15.2M
Mechanisms of LRRK2 Mediated NeurotoxicityR01NS064934 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEST, ANDREW B · 2010 to 2025
$6.3M
Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's diseaseR01NS119528 · NINDS · DUKE UNIVERSITY · PI SANDERS, LAURIE H · 2020 to 2024
$2.9M
Identifying kinase signaling pathways linked to tau-mediated neurodegenerationR21AG084216 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, TODD JONATHAN, SANDERS, LAURIE H · 2023 to 2024
$449k
NIA NIH HHS P01 AG066597NIA NIH HHS P01 AG084497NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072979NIA NIH HHS R21 AG084216NIA NIH HHS U19 AG066567NINDS NIH HHS R01 NS064934NINDS NIH HHS R01 NS119528
6 · The paper itself

Abstract

Parkinson's disease (PD) pathogenic mutations in

Indexed as

Alzheimer’s diseaseLRRK2Parkinson’s diseaseRab12synucleintau

Identifiers

PMID40661559
PMCPMC12258990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.