ArticlebioRxiv : the preprint server for biology2025
Systematic characterization of the ovarian landscape across mouse menopause models.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Menopause not only affects fertility but also has widespread impact on systemic health. Yet, the molecular mechanisms underlying this process are not fully understood, partly due to the absence of robust, age-relevant preclinical models with comprehensive molecular and phenotypic characterization. To address this, we systematically compared three candidate mouse models of menopause: (1) intact aging, (2) chemical ovarian follicle depletion using 4-vinylcyclohexene diepoxide (VCD) administered at multiple ages, and (3)
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