ArticlebioRxiv : the preprint server for biology2025
Glis3 is a modifier of cyst progression in autosomal dominant polycystic kidney disease.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations affecting polycystin-1 (PC1) or -2 (PC2). The existence of a 'cilia-dependent cyst activation' (CDCA) pathway has been identified by demonstrating that structurally intact primary cilia are crucial for cyst growth following loss of polycystins. We previously used translating ribosome affinity purification (TRAP) RNA-Seq on pre-cystic mouse kidneys to determine the translatome that meet the criteria for CDCA and identified Methods: We used live cell confocal imaging to study the subcellular localization of Glis3 in the presence or absence of Results: The ciliary localization of Glis3 is not affected by Pkd1 mutation status. Kidney selective Conclusions: Glis3 is a primary cilium localized transcription factor that genetically interacts with
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