Evidence map›Paper›PMID 40661531›Full record

ArticlebioRxiv : the preprint server for biology2025

Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.

Lucas G Vattino, Kameron K Clayton, Troy A Hackett, Anne E Takesian, Daniel B Polley

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lucas G VattinoEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, 02114, USA.ORCID 0000-0001-6340-844X
Kameron K ClaytonEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, 02114, USA.ORCID 0000-0002-0045-4286
Troy A HackettVanderbilt School of Medicine, Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID 0000-0003-1743-4975
Anne E TakesianEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, 02114, USA.ORCID 0000-0002-1048-7356
Daniel B PolleyEaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, 02114, USA.ORCID 0000-0002-5120-2409

Funding

Corticofugal Circuits for Active ListeningR01DC017078 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Daniel B. Polley · 2018 to 2026
$5.6M
Diverse Cortical Layer 1 Circuits forAuditory Processing and PlasticityR01DC018353 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI ANNE E TAKESIAN · 2020 to 2026
$3.2M
Identification of Cellular Phenotypes in the Auditory ForebrainR01DC015388 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HACKETT, TROY A. · 2016 to 2020
$1.7M
NIDCD NIH HHS R01 DC015388NIDCD NIH HHS R01 DC017078NIDCD NIH HHS R01 DC018353
6 · The paper itself

Abstract

Basal forebrain cholinergic neurons (BFCNs) densely innervate auditory cortex (ACtx), conveying signals linked to internal brain states and external sensory cues. Several studies have shown that acetylcholine (ACh) rapidly modifies local cortical circuits via nicotinic ACh receptors (nAChRs) on layer 1 (L1) inhibitory neurons. BFCN terminals are also abundant in L6, though the mechanisms and functional consequences of cholinergic modulation in deeper cortical layers has received less attention. Here, we performed multi-plex

Identifiers

PMID40661531
PMCPMC12259054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.