ArticlebioRxiv : the preprint server for biology2025
Spatial image gradient estimation from the diffusion MRI profile.
Iman Aganj, Thorsten Feiweier, John E Kirsch, Bruce R Fischl, Andre J van der Kouwe
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
5 authors.
Iman AganjAthinoula A. Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4673-1293 Thorsten FeiweierResearch & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany.
John E KirschAthinoula A. Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Bruce R FischlAthinoula A. Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Andre J van der KouweAthinoula A. Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Funding
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4MMRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5MThe Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1MTraining and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9MProject 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8MImaging and Analysis Techniques to Construct a Cell Census Atlas of the Human Brain Admin SupplementU01MH117023 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A, FISCHL, BRUCE · 2018 to 2022
$7.6MAn Acquisition and Analysis Pipeline for Integrating MRI and Neuropathology in TBI-related Dementia and VCIDU24NS135561 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Susie Yi Huang · 2023 to 2026
$6.1MNeuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1MFreeSurfer Development, Maintenance, and HardeningR01EB023281 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl, Douglas Nowlin Greve · 2016 to 2026
$5.6MA Longitudinal Analysis Stream for FreeSurferR01NS083534 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2014 to 2026
$4.6MDeep Learning Algorithms for FreeSurferR01AG064027 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2020 to 2024
$3.4MSegmenting Brain Structures for Neurological DisordersR01NS105820 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Bruce Fischl · 2019 to 2026
$3.2MNCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG064027NIA NIH HHS R01 AG068261NIA NIH HHS R01 AG070988NIA NIH HHS R01 AG079422NIA NIH HHS RF1 AG068261NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41 EB030006NIBIB NIH HHS R01 EB006758NIBIB NIH HHS R01 EB019956NIBIB NIH HHS R01 EB023281NIBIB NIH HHS R21 EB018907NIMH NIH HHS RF1 MH121885NIMH NIH HHS RF1 MH123195NIMH NIH HHS U01 MH093765NIMH NIH HHS U01 MH117023NINDS NIH HHS R01 NS070963NINDS NIH HHS R01 NS083534NINDS NIH HHS R01 NS105820NINDS NIH HHS R21 NS072652NINDS NIH HHS U01 NS086625NINDS NIH HHS U24 NS135561
6 · The paper itselfAbstract
Purpose: In the course of diffusion, water molecules experience varying values for the relaxation-time properties of the underlying tissue. This factor, which has rarely been accounted for in diffusion MRI (dMRI), is modeled in this work, allowing for the estimation of the gradient of the relaxation-time properties from the dMRI signal. Methods: With the aim of mining the dMRI data for information about the spatial variations in the tissue relaxation-time properties, a new mathematical relationship between the diffusion signal and the spatial gradient of the image is derived, enabling the estimation of the latter from the former. The hypothesis was validated on human brain dMRI images from three datasets: the public Human Connectome Project Young Adults database, 10 healthy volunteers and 1 Results: The image spatial gradient estimated from the diffusion signal was compared to the gold-standard spatial gradient approximated through the finite difference. The former gradient was significantly related to the latter in all datasets (i.e., with a difference significantly smaller than chance), with an effect distinct from fiber continuity. Conclusion: The results support the hypothesized relationship between within-voxel dMRI signal and image gradient, with an effect that was not explainable by the confounding factor of fiber continuity.
Indexed as
Diffusion MRI (dMRI)relaxation timespatial gradientstimulated echo (STE)
Identifiers
PMID40661526
PMCPMC12258976
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