Evidence map›Paper›PMID 40661522›Full record

ArticlebioRxiv : the preprint server for biology2025

ECgo: All-Optical Induction of Single Endothelial Cell Injury and Capillary Occlusion in the Brain.

Jacqueline Condrau, Srinivasa R Allu, Tatiana V Esipova, Eva Erlebach, Matthias T Wyss, Chaim Glück, Luca Ravotto, Thomas Troxler, Marco Villa, Paola Ceroni and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jacqueline CondrauInstitute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland.
Srinivasa R AlluDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tatiana V EsipovaDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eva ErlebachInstitute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland.
Matthias T WyssInstitute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland.
Chaim GlückInstitute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland.
Luca RavottoInstitute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland.
Thomas TroxlerDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Marco VillaG. Ciamician Department of Chemistry, University of Bologna, Bologna 40126, Italy.
Paola CeroniG. Ciamician Department of Chemistry, University of Bologna, Bologna 40126, Italy.
Mohamad El AmkiNeuroscience Center Zurich, University and ETH Zurich, Zurich 8057, Switzerland.ORCID 0000-0003-1245-5283
Sergei A VinogradovDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bruno WeberInstitute of Pharmacology and Toxicology, University of Zurich, Zurich 8057, Switzerland.

Funding

Oxygen imaging by phosphorescence quenchingU24EB028941 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI VINOGRADOV, SERGEI · 2019 to 2023
$1.6M
Enabling widespread use of high resolution imaging of oxygen in the brainR24NS092986 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BOAS, DAVID A, VINOGRADOV, SERGEI · 2015 to 2018
$1.2M
NIBIB NIH HHS U24 EB028941NINDS NIH HHS R24 NS092986
6 · The paper itself

Abstract

The ability to induce endothelial cell (EC) damage in the mouse brain with high spatial precision is invaluable for mechanistic studies of brain capillary injury and repair. Here, we introduce an optical method, termed ECgo, that utilizes a new two-photon-excitable porphyrin-based photosensitizer (

Indexed as

brain capillariesCerebral blood flowmicrostrokephotodynamic therapyporphyrins

Identifiers

PMID40661522
PMCPMC12258731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.