Evidence map›Paper›PMID 40661510›Full record

ArticlebioRxiv : the preprint server for biology2025

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis.

Peter Georgiev, Sheila Johnson, Kiran Kurmi, Song-Hua Hu, SeongJun Han, Dillon Patterson, Thao H Nguyen, Linglin Huang, Dan Liang, Naomi Goldman and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Peter GeorgievDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Sheila JohnsonDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0001-5062-7934
Kiran KurmiDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Song-Hua HuDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
SeongJun HanDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Dillon PattersonDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Thao H NguyenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Linglin HuangGene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Dan LiangDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Naomi GoldmanDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Thomas ConwayDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Hannah CreaseyDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jared RoweDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Marcia C HaigisDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0003-2530-2681
Arlene H SharpeDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0002-9736-2109

Funding

Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI FREEMAN, GORDON JAMES · 2003 to 2023
$42.5M
Understanding and Overcoming T cell Immunosuppression in GlioblastomaP01CA236749 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI E. Antonio Chiocca · 2020 to 2026
$19.5M
Defining mechanisms to promote antitumor immunity by modulating one-carbon metabolismR01CA276866 · NCI · HARVARD MEDICAL SCHOOL · PI MARCIA HAIGIS, Arlene H. Sharpe · 2023 to 2026
$2.2M
Progenitor cell states contributing to aging and lung cancerU01CA267827 · NCI · HARVARD MEDICAL SCHOOL · PI HAIGIS, MARCIA, KIM, CARLA F. · 2021 to 2025
$2.2M
Metabolic regulation of the anti-tumor CD8+ T cell response to PD-1 by asparagineF31CA281090 · NCI · HARVARD MEDICAL SCHOOL · PI GEORGIEV, PETER · 2023 to 2024
$61k
NCI NIH HHS F31 CA281090NCI NIH HHS P01 CA236749NCI NIH HHS R01 CA276866NCI NIH HHS U01 CA267827NIAID NIH HHS P01 AI056299
6 · The paper itself

Abstract

Amino acids play critical roles in the activation and function of lymphocytes. Here we show that the non-essential amino acid, asparagine, is essential for optimal activation and proliferation of CD4

Identifiers

PMID40661510
PMCPMC12259033

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.