Evidence map›Paper›PMID 40661492›Full record

ArticlebioRxiv : the preprint server for biology2025

Magnetoelectric nanodiscs diminish motor deficits in a model of Parkinson's disease.

Ye Ji Kim, Antoine De Comite, Emmanuel Vargas Paniagua, Sharmelee Selvaraji, Ethan Frey, Rajib Mondal, Nidhi Seethapathi, Polina Anikeeva

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ye Ji KimDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-1170-6119
Antoine De ComiteMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-3852-0402
Emmanuel Vargas PaniaguaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sharmelee SelvarajiResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ethan FreyDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Rajib MondalResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nidhi SeethapathiMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-5159-9717
Polina AnikeevaDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-6495-5197

Funding

Fusion of nanomagnetic and viral tools to interrogate brain-body circuitsDP1AT011991 · NCCIH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2021 to 2025
$5.3M
NCCIH NIH HHS DP1 AT011991
6 · The paper itself

Abstract

Deep brain stimulation (DBS) with electrodes implanted in the subthalamic nucleus (STN) alleviates motor symptoms in Parkinson's disease (PD). However, the surgical complexity and associated side effects limit deployment of DBS to late-stage patients. Here, we explore a neuromodulation approach that employs locally injected magnetoelectric nanodiscs (MENDs) as an alternative to electrode-based DBS. The MENDs, composed of Fe

Identifiers

PMID40661492
PMCPMC12258929

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.