Evidence map›Paper›PMID 40661469›Full record

ArticlebioRxiv : the preprint server for biology2025

Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta.

Parul Khajuria, Dilpreet Kour, Kuhu Sharma, Lakhvinder Singh, Razia Banoo, Diksha Manhas, P Ramajayan, Utpal Nandi, Sandip Bharate, Zabeer Ahmed and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Parul KhajuriaPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
Dilpreet KourPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
Kuhu SharmaPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
Lakhvinder SinghPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
Razia BanooAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Diksha ManhasPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
P RamajayanPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
Utpal NandiPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
Sandip BharateAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Zabeer AhmedPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.
Ajay KumarPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu-180016, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AD pathology is accompanied by increased senescence and reduced levels of autophagy in the brain. We investigated whether pharmacologically inducing autophagy could alter the senescent phenotype and help ameliorate AD pathology. We discovered that Bisdemethoxycurcumin (BDMC), a natural compound found in

Indexed as

3xTg-AD miceAlzheimer diseaseAmyloid betaAstrocytesAutophagyBisdemethoxycurcuminSenescence

Identifiers

PMID40661469
PMCPMC12258734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.