Evidence map›Paper›PMID 40661465›Full record

ArticlebioRxiv : the preprint server for biology2025

Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse

Stephen A Banse, Christine A Sedore, Anna L Coleman-Hulbert, Erik Johnson, Brian Onken, David Hall, Erik Segerdell, E Grace Jones, Yuhua Song, Hadley Osman and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Stephen A BanseInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.ORCID 0000-0002-5540-4526
Christine A SedoreInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Anna L Coleman-HulbertInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.ORCID 0000-0001-8090-551X
Erik JohnsonInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Brian OnkenRutgers University, Dept. of Molecular Biology and Biochemistry, Piscataway, NJ, 08854, USA.
David HallThe Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Erik SegerdellInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
E Grace JonesInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Yuhua SongRutgers University, Dept. of Molecular Biology and Biochemistry, Piscataway, NJ, 08854, USA.
Hadley OsmanThe Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Jian XueRutgers University, Dept. of Molecular Biology and Biochemistry, Piscataway, NJ, 08854, USA.
Elena BattistoniThe Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Suzhen GuoRutgers University, Dept. of Molecular Biology and Biochemistry, Piscataway, NJ, 08854, USA.
Anna C FoulgerThe Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Madhuri AchantaRutgers University, Dept. of Molecular Biology and Biochemistry, Piscataway, NJ, 08854, USA.
Mustafa SheikhThe Buck Institute for Research on Aging, Novato, CA, 94945, USA.
Theresa FitzgibbonThe Buck Institute for Research on Aging, Novato, CA, 94945, USA.
John H WillisInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Gavin C WoodruffInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.
Monica DriscollRutgers University, Dept. of Molecular Biology and Biochemistry, Piscataway, NJ, 08854, USA.ORCID 0000-0002-8751-7429
Gordon J LithgowThe Buck Institute for Research on Aging, Novato, CA, 94945, USA.ORCID 0000-0002-8953-3043
Patrick C PhillipsInstitute of Ecology and Evolution, University of Oregon, Eugene, OR 97403, USA.ORCID 0000-0001-7271-342X

Funding

Discovering compounds with robust pro-longevity activitiesU01AG045844 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Gordon J Lithgow · 2013 to 2026
$10.1M
Healthspan Analysis of C. elegans Strains Treated with Candidate Anti Aging InterU01AG045864 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI MONICA A. DRISCOLL · 2013 to 2026
$8.1M
Genetic variation underlying the response to longevity interventionsU01AG045829 · NIA · UNIVERSITY OF OREGON · PI Patrick C. Phillips · 2013 to 2026
$8.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Caenorhabditis Testing Program Data Coordinating CenterU24AG056052 · NIA · UNIVERSITY OF OREGON · PI Patrick C. Phillips · 2017 to 2026
$2.2M
NIA NIH HHS U01 AG045829NIA NIH HHS U01 AG045844NIA NIH HHS U01 AG045864NIA NIH HHS U24 AG056052NIH HHS P40 OD010440
6 · The paper itself

Abstract

Aging is a pan-metazoan process with significant consequences for human health and society-discovery of new compounds that ameliorate the negative health impacts of aging promise to be of tremendous benefit across a number of age-based comorbidities. One method to prioritize a testable subset of the nearly infinite universe of potential compounds is to use computational prediction of their likely anti-aging capacity. Here we present a survey of longevity effects for 16 compounds suggested by a previously published computational prediction set, capitalizing upon the comprehensive, multi-species approach utilized by the

Indexed as

aak-2akt-1akt-2aldosteroneall-trans retinoic acidarecolineberberinebortezomibCaenorhabditis briggsaeCaenorhabditis elegansCaenorhabditis tropicalisCITPcomputational predictionsdaf-16dasatinibdecitabinedexamethasoneeat-2erlotinibeverolimusfisetingefitinibhealthspanhsf-1longevitymetoprololpmk-1propranololritonavirRNAseqskn-1temsirolimusthalidomidetol-1

Identifiers

PMID40661465
PMCPMC12258912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.