Evidence map›Paper›PMID 40661455›Full record

ArticlebioRxiv : the preprint server for biology2025

Dynamic regulation of the COPII interactome and collagen trafficking by site-specific glycosylation of Sec24D.

Tetsuya Hirata, Dharmendra Choudhary, Brittany J Bisnett, Erik J Soderblom, Ela W Knapik, Michael Boyce

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tetsuya HirataDepartment of Biochemistry, Duke University School of Medicine.
Dharmendra ChoudharyDepartments of Medicine, Division of Genetic Medicine, Vanderbilt Genetic Institute, Vanderbilt University Medical Center.
Brittany J BisnettDepartment of Biochemistry, Duke University School of Medicine.
Erik J SoderblomProteomics and Metabolomics Shared Resource, Duke University School of Medicine.
Ela W KnapikDepartments of Medicine, Division of Genetic Medicine, Vanderbilt Genetic Institute, Vanderbilt University Medical Center.
Michael BoyceDepartment of Biochemistry, Duke University School of Medicine.ORCID 0000-0002-2729-4876

Funding

Discovering Biology for Neuropsychiatric Diseases Through Omics Studies on ComorbiditiesR01MH113362 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COX, NANCY J, KNAPIK, ELA W · 2017 to 2021
$3.9M
Control of COPII vesicle trafficking by intracellular protein glycosylationR01GM117473 · NIGMS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S · 2017 to 2025
$2.6M
NIGMS NIH HHS R01 GM117473NIMH NIH HHS R01 MH113362
6 · The paper itself

Abstract

Coat protein complex II (COPII) mediates anterograde trafficking from the endoplasmic reticulum (ER). While the core COPII machinery is well-characterized, how cells regulate COPII to accommodate large cargoes, including collagens, remains incompletely understood. Here, we show that the cargo-selecting COPII subunit Sec24D is modified by site-specific O-linked β-

Indexed as

CollagenCOPIIMYOFO-GlcNAcylationprotein-protein interactionprotein transportSec24Dsignaling

Identifiers

PMID40661455
PMCPMC12259161

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.