Evidence map›Paper›PMID 40661430›Full record

ArticlebioRxiv : the preprint server for biology2025

Metabolism of epigenetic ribonucleosides leads to nucleolar stress and cytotoxicity.

Xuemeng Sun, Anita Donlic, Jacob A Boyer, Neal Reddy, Clifford P Brangwynne, Joshua D Rabinowitz, Ralph E Kleiner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Xuemeng SunDepartment of Chemistry, Princeton University, Princeton, NJ 08544.
Anita DonlicOmenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ 08544.
Jacob A BoyerDepartment of Chemistry, Princeton University, Princeton, NJ 08544.
Neal ReddyDepartment of Chemistry, Princeton University, Princeton, NJ 08544.
Clifford P BrangwynneOmenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ 08544.
Joshua D RabinowitzDepartment of Chemistry, Princeton University, Princeton, NJ 08544.
Ralph E KleinerDepartment of Chemistry, Princeton University, Princeton, NJ 08544.

Funding

Chemical Approaches to Illuminate the Epitranscriptome (Administrative/Equipment Supplement)R01GM132189 · NIGMS · PRINCETON UNIVERSITY · PI KLEINER, RALPH ELLIOT · 2019 to 2023
$1.6M
NIGMS NIH HHS R01 GM132189
6 · The paper itself

Abstract

Post-transcriptional RNA modifications are ubiquitous in biology, but the fate of epigenetic ribonucleotides after RNA turnover and the consequences of their metabolism and misincorporation into nucleic acids are largely unknown. Here we explore the metabolism of epigenetic ribonucleosides in human cells by studying effects on cell growth, quantifying misincorporation into cellular RNAs and identifying metabolic regulators, and exploring phenotypes associated with cytotoxicity. We find that bulky N

Identifiers

PMID40661430
PMCPMC12259108

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.