Evidence map›Paper›PMID 40661421›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural basis of RNA-guided transcription by a dCas12f-σ

Renjian Xiao, Florian T Hoffmann, Dan Xie, Tanner Wiegand, Adriana I Palmieri, Samuel H Sternberg, Leifu Chang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Renjian XiaoDepartment of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907, USA.ORCID 0000-0002-5914-0812
Florian T HoffmannDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-0301-4259
Dan XieDepartment of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907, USA.
Tanner WiegandDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-0528-268X
Adriana I PalmieriDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-8240-9114
Leifu ChangDepartment of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907, USA.ORCID 0000-0002-6107-5271

Funding

Molecular basis for CRISPR RNA-guided nucleic acid cleavage and DNA transpositionR01GM138675 · NIGMS · PURDUE UNIVERSITY · PI CHANG, LEIFU · 2020 to 2024
$1.8M
NIGMS NIH HHS R01 GM138675
6 · The paper itself

Abstract

RNA-guided proteins have emerged as critical transcriptional regulators in both natural and engineered biological systems by modulating RNA polymerase (RNAP) and its associated factors

Identifiers

PMID40661421
PMCPMC12259091

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.