Evidence map›Paper›PMID 40661409›Full record

ArticlebioRxiv : the preprint server for biology2025

Exapted CRISPR-Cas12f homologs drive RNA-guided transcription.

Florian T Hoffmann, Tanner Wiegand, Adriana I Palmieri, Juniper Glass-Klaiber, Renjian Xiao, Stephen Tang, Hoang Le, Chance Meers, George D Lampe, Leifu Chang and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Florian T HoffmannDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-0301-4259
Tanner WiegandDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-0528-268X
Adriana I PalmieriDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Juniper Glass-KlaiberDepartment of Cellular Physiology and Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-9212-725X
Renjian XiaoDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-5914-0812
Stephen TangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-5492-9796
Hoang LeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0009-0003-7911-881X
Chance MeersDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0003-2554-3987
George D LampeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0002-2873-2372
Leifu ChangDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-6107-5271
Samuel H SternbergDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID 0000-0001-8240-9114

Funding

Molecular basis for CRISPR RNA-guided nucleic acid cleavage and DNA transpositionR01GM138675 · NIGMS · PURDUE UNIVERSITY · PI CHANG, LEIFU · 2020 to 2024
$1.8M
Mechanisms of reverse transcriptase mediated phage resistance in EnterobacteriaceaeF30AI183830 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen Tang · 2024 to 2026
$158k
NIAID NIH HHS F30 AI183830NIGMS NIH HHS R01 GM138675
6 · The paper itself

Abstract

Bacterial transcription initiation is a tightly regulated process that canonically relies on sequence-specific promoter recognition by dedicated sigma (σ) factors, leading to functional DNA engagement by RNA polymerase (RNAP)

Identifiers

PMID40661409
PMCPMC12259090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.