Evidence map›Paper›PMID 40661401›Full record

ArticlebioRxiv : the preprint server for biology2025

Sensory stimuli and cilium trafficking defects trigger the release of ciliary extracellular vesicles from multiple ciliary locations.

Teresa Lobo, Guus H Haasnoot, Aleksandra Nawrocka, Christine W Bruggeman, Adria Razzauti, Erwin J G Peterman, Patrick Laurent

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Teresa LoboLaboratory of Neurophysiology, ULB Institute for Neuroscience, Université Libre de Bruxelles, 1070 Bruxelles, Belgium.
Guus H HaasnootLaserLaB and Department of Physics and Astronomy, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands.ORCID 0000-0003-2551-1707
Aleksandra NawrockaLaboratory of Neurophysiology, ULB Institute for Neuroscience, Université Libre de Bruxelles, 1070 Bruxelles, Belgium.
Christine W BruggemanLaserLaB and Department of Physics and Astronomy, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands.ORCID 0000-0003-0908-3562
Adria RazzautiLaboratory of Neurophysiology, ULB Institute for Neuroscience, Université Libre de Bruxelles, 1070 Bruxelles, Belgium.
Erwin J G PetermanLaserLaB and Department of Physics and Astronomy, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands.ORCID 0000-0003-1058-249X
Patrick LaurentLaboratory of Neurophysiology, ULB Institute for Neuroscience, Université Libre de Bruxelles, 1070 Bruxelles, Belgium.ORCID 0000-0001-5360-5597

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

The primary cilium is a signaling organelle that extends from many cell types to detect and relay extracellular signals. Beyond its signaling role, the cilium also produces cilia-derived extracellular vesicles (cEVs), although the mechanisms underlying their biogenesis and functions remain poorly understood. We characterized the cEV biogenesis in vivo using ciliated sensory neurons of

Identifiers

PMID40661401
PMCPMC12258979

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.