ArticlebioRxiv : the preprint server for biology2025
Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
RNA-binding proteins (RBPs) play important roles in mRNA transcription, processing, and translation. Chemical tools are lacking for RBPs, which has hindered efforts to perturb and understand RBP function in cells. We recently reported a chloroacetamide compound ( Highlights: Co-crystal structure reveals how covalent ligands stereoselectively bind NONOChlorofluoroacetamides (CFAs) bind NONO with high proteomic selectivityCFA ligands remodel cancer cell transcriptomes in a NONO-dependent mannerCFA ligands suppress cancer cell growth in a NONO-dependent manner.
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