Evidence map›Paper›PMID 40661383›Full record

ArticlebioRxiv : the preprint server for biology2025

CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice.

Valentina Cea Salazar, Arjen J Boender, Adele M H Seelke, Liam Gaard, Sabrina L Mederos, Sophia Rogers, Xiomara Z Gutierrez, Karen L Bales, Larry J Young, Brian C Trainor

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Valentina Cea SalazarNeuroscience Graduate Group, University of California, Davis, USA.
Arjen J BoenderAchucarro Basque Center for Neuroscience, Leioa, Spain.
Adele M H SeelkeDepartment of Psychology, University of California, Davis, USA.
Liam GaardDepartment of Psychology, University of California, Davis, USA.
Sabrina L MederosAnimal Behavior Graduate Group, University of California, Davis, USA.
Sophia RogersDepartment of Psychology, University of California, Davis, USA.
Xiomara Z GutierrezDepartment of Psychology, University of California, Davis, USA.
Karen L BalesDepartment of Psychology, University of California, Davis, USA.
Larry J YoungEmory National Primate Research Center, Emory University, Atlanta, GA, USA.
Brian C TrainorNeuroscience Graduate Group, University of California, Davis, USA.

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The Impact of Oxytocin on the Neural Representation Social Stimuli P50MH100023 · NIMH · EMORY UNIVERSITY · PI YOUNG, LARRY J · 2013 to 2022
$21.8M
Genetic Regulation of Variability in Brain Oxytocin ReceptorsR01MH112788 · NIMH · EMORY UNIVERSITY · PI YOUNG, LARRY J · 2018 to 2022
$2.5M
Supplement: Oxytocin-department circuits of social approach and vigilanceR01MH121829 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TRAINOR, BRIAN C · 2020 to 2024
$2.0M
NIH HHS P51 OD011132NIMH NIH HHS P50 MH100023NIMH NIH HHS R01 MH112788NIMH NIH HHS R01 MH121829
6 · The paper itself

Abstract

Oxytocin receptors (OTRs) within the extended amygdala and nucleus accumbens (NAc) have been implicated in modulating social behaviors, particularly following stress. The effects of OTR could be mediated by modulating the activity of pre-synaptic axon terminals or via receptors in post-synaptic neurons or glia. Using a viral-mediated CRISPR/Cas9 gene editing system in female California mice (

Identifiers

PMID40661383
PMCPMC12259110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.